Table 3.
Gene Expression in Pituitaries and Hypothalami of Twin Fetuses Treated With icv E2SO4 Relative to Fetuses Treated With Vehicle a
| Gene | E2SO4 Treated (% Control Fetus) |
|---|---|
| CRH (hypothalamus) | 56 ± 7 b |
| AVP (hypothalamus) | 65 ± 37 |
| POMC (pituitary) | 42 ± 9 b |
| PC-1 (pituitary) | 146 ± 40 |
| LH (pituitary) | 96 ± 40 |
| FSH (pituitary) | 8 ± 3 b |
| PRL (pituitary) | 111 ± 20 |
Abbreviations: AVP, arginine vasopressin; CRH, corticotrophin-releasing hormone; icv, intracerebroventricularly; mRNA, messenger RNA; POMC, proopiomelanocortin; PC-1, prohormone convertase 1; LH, luteinizing hormone; FSH, follicle-stimulating hormone; PRL, prolactin; E2SO4, estradiol-3-sulfate.
a Data are reported as the percentage level of control fetus mRNA expression levels.
b Statistical significance P < .05.