Table 4.

Estrogen Receptors-α, -β, PGHS-1, and PGHS-2 mRNA Abundance in Pituitary and Brain Regions of Twin Fetuses Treated With icv E₂SO₄ or Vehicle ^a

Tissue	ER-α (% Control)	ER-β (% Control)	PGHS-1 (% Control)	PGHS-2 (% Control)
Pituitary	41 ± 8 b	128 ± 50	64 ± 19	136 ± 57
Hypothalamus	72 ± 14	59 ± 16	118 ± 35	262 ± 159
Medullary Brain stem	184 ± 90	86 ± 17	93 ± 33	102 ± 28
Hippocampus	59 ± 2 c	73 ± 19	79 ± 6	85 ± 7
Cerebellum	126 ± 56	76 ± 15	71 ± 25	83 ± 21
Cerebral cortex	72 ± 14	88 ± 25	120 ± 30	62 ± 14

Abbreviations: E₂SO₄, estradiol-3-sulfate; PGHS, prostaglandin endoperoxide synthase; mRNA, messenger RNA; icv, intracerebroventricularly;

^a Data are reported as the percentage level of control fetus mRNA expression levels.

^b Statistical significance P < .05.

^c Statistical significance p = 0.001