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. Author manuscript; available in PMC: 2011 Dec 12.
Published in final edited form as: Sci Transl Med. 2011 Nov 30;3(111):111ra120. doi: 10.1126/scitranslmed.3003130

Figure 1. Th1 Cell-Mediated xGVHD in an LPS Model is Prevented by PDL1-expressing Effector T Cells.

Figure 1

Th1 cells were adoptively transferred to rag2−/−cγ−/− mice alone or in combination with control-LV transduced T cells, Treg cells, or PDL1-transduced T cells. (a) The percentage of IFN-γ secreting human T cells 5 days after adoptive transfer. (b) Absolute number of post-transplant splenic IFN-γ+ human T cells was quantified for each cohort. (c) Recipients were challenged with LPS and serum was harvested after 90 min and evaluated for TNF-α content. (d) Cohorts of host mice received the human cell inocula specified, followed by LPS administration at day 5 after transfer to induce lethal cytokine-mediated xGVHD (n, number per cohort: M, × 106). (e) Survival curve after xGVHD induction (* indicates p ≤ 0.05; *** indicates p ≤ 0.005).