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. Author manuscript; available in PMC: 2012 Dec 5.
Published in final edited form as: Mol Pharm. 2011 Nov 8;8(6):2039–2049. doi: 10.1021/mp200421k

Figure 13.

Figure 13

Repeating treatment (gray) controls the cancer population (red) while the fibroblast population (blue) gradually reduces. We simulate a mixed tumour of cancer cells and fibroblasts. Targeted therapy reduces the cancer cell population but not the fibroblasts. However, without stimulation, the fibroblast population declines naturally. Repeating treatment controls the cancer cell population, allowing the fibroblast population to revert to normal levels. After several treatments, the tumour regrows slowly, without flare.