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. Author manuscript; available in PMC: 2012 Oct 28.
Published in final edited form as: Circ Res. 2011 Sep 15;109(10):1162–1172. doi: 10.1161/CIRCRESAHA.111.253807

Figure 1. A prospective test of the “aerobic hypothesis” in rats selectively bred to contrast for intrinsic endurance exercise capacity.

Figure 1

Data collected in Trondheim, Norway. (A) Survival curves are significantly different between Low Capacity Runners (LCR; n = 23) and High Capacity Runners (HCR: n = 23). Logrank test; (P<0.0001). (B-E) Maximal oxygen consumption (VO2max) assessed longitudinally at 15, 20, 25, and 34 months of age predicted lifespan both between and within selected lines. (F) PGC-1α and UCP2 in left ventricular tissue. (G) Total antioxidant status in plasma (TAS).