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. Author manuscript; available in PMC: 2012 Oct 28.
Published in final edited form as: Circ Res. 2011 Sep 15;109(10):1162–1172. doi: 10.1161/CIRCRESAHA.111.253807

Figure 4. Sarcoplasmic reticulum Ca2+ leak was more compromised in LCR rats compared with HCR rats, and this difference was sustained with aging.

Figure 4

(A) Example confocal images of Ca2+ sparks from quiescent cells. (B-E) Ca2+ spark frequency, amplitude, and width and duration at half-maximum amplitude were higher in LCR than HCR rats, indicating increased loss of sarcoplasmic reticulum Ca2+. (F&G) Quantitative assessments of sarcoplasmic reticulum Ca2+ leak confirmed that cells of old LCR rats had greater Ca2+ leak than HCR equivalents. Adult: 15-20 months; Old Age: >25 months. *: p<0.05 age-matched LCR vs. HCR.