Table 2.
Literature Data for Potencies to Activate TAAR1
Compound | EC50 (μM) | |||
---|---|---|---|---|
Rat | Mouse | Human-rat | Human | |
(S)-1 | 0.8114 | 0.2114 | 1.1214 | 0.99 ± 0.1615 |
0.44 ± 0.0112 | 0.002 ± 0.00116 | 0.14 ± 0.0130 | ||
1.2 ± 0.0715 | ||||
(R)-1 | 0.2814 | 4.9614 | 3.0914 | 1.7 ± 0.2915 |
0.21 ± 0.0412 | 0.065 ± 0.05316 | 0.25 ± 0.0130 | ||
1.4 ± 0.615 | ||||
(rac)-2 | 0.05 ± 0.0112 | |||
(S)-2 | 0.1914 | 0.2814 | >5.4214 | |
(R)-2 | 0.0614 | 5.6514 | >8.5412,14 | |
(rac)-4 | 1.7 ± 1.212 | |||
(S)-4 | 0.37 ± 0.0530 | |||
(S)-10 | 0.8914 | 0.9214 | 4.4414 | 1.3 ± 0.1930 |
0.07 ± 0.0816 | ||||
(R)-10 | 1.1914 | 2.4414 | 9.8314 |