Table 1.
Partner gene | Chromosome | Disease | Relevant domain(s) | Reference(s) |
---|---|---|---|---|
HOXA9 | 7p15 | MDS, AML, CML, CMML | HD | 6,7 |
HOXA11 | 7p15 | MDS, AML, CML, JMML | HD | 135 |
HOXA13 | 7p15 | AML | HD | 136 |
HOXC11 | 12q13 | AML | HD | 137 |
HOXC13 | 12q13 | AML | HD | 138 |
HOXD11 | 2q31 | AML | HD | 139 |
HOXD13 | 2q31 | MDS, AML, CML | HD | 42 |
PMX1 | 1q23 | AML, CML | HD | 140 |
PMX2 | 9q34 | AML | HD | 141 |
HHEX | 10q23 | AML | HD | 58 |
PHF23 | 17p13 | AML | PHD, CC | 142 |
JARID1A | 12p13 | AML | PHD, CC | 143 |
NSD1 | 5q35 | MDS, AML, T-ALL | PHD, CC, SET | 144 |
NSD3 | 8p11 | MDS, AML | PHD, CC, SET | 145 |
MLL | 11q23 | AML | PHD, CC, SET | 121 |
SETBP1 | 18q12 | T-ALL | CC | 35 |
LEDGF | 9p22 | AML, CML | CC | 43 |
CCDC28 | 6q24 | AML, T-ALL | CC | 146 |
HMGB3 | Xq28 | AML | CC | 147 |
IQCG | 3q29 | T-ALL | CC | 34 |
RAP1GDS1 | 4q21 | AML, T-ALL | CC | 33 |
ADD3 | 10q25 | AML, T-ALL | CC | 32 |
DDX10 | 11q22 | MDS, AML, CML, CMML | CC | 148 |
TOP1 | 20q11 | MDS, AML | CC | 149 |
TOP2B | 3p24 | AML | CC | 150 |
LNP1 | 3q12 | AML | CC | 151 |
RARG | 12q13 | AML | CC | 36 |
ANKRD28 | 3p25 | AML | Ankyrin | 152 |
CMML indicates chronic myelomonocytic leukemia; JMML, juvenile myelomonocytic leukemia; and CC, coiled-coil.