Table 2.
Murine models of NUP98 fusions
| Fusion gene | Phenotype | Method | Reference(s) |
|---|---|---|---|
| NUP98-HOXA9 | MPN progressing to AML (mean latency, 230 d) | BMT | 48 |
| NUP98-HOXA9 | MPN progressing to AML (mean latency, 450 d) | Transgenic | 49 |
| NUP98-HOXA9 and Meis1 | MPN progressing to AML (mean latency, 142 d) | BMT | 48 |
| NUP98-HOXA9 and BCR-ABL | AML (latency, 21 d) | BMT | 123 |
| NUP98-HOXA9 and TEL-PDGFβR | AML (latency, 25 d) | BMT | 123 |
| NUP98-HOXA10 | MPN progressing to AML (mean latency, 223 d) | BMT | 50,51 |
| NUP98-HOXA10 and Meis1 | MPN progressing to AML (mean latency, 70 d) | BMT | 50,51 |
| NUP98-HOXD13 | MPN, not progressing to AML | BMT | 38 |
| NUP98-HOXD13 and Meis1 | MPN progressing to AML (median latency, 75 d) | BMT | 38 |
| NUP98-HOXD13 | MDS progressing to AML (median latency, 9 mo) | Transgenic | 54,55 |
| NUP98-PMX1 | MPN (mean latency, 246 d) | BMT | 57 |
| NUP98-PMX1 and Meis1 | MPN progressing to AML (median latency, 191 d) | BMT | 57 |
| NUP98-HHEX | AML (mean latency, 9 mo) | BMT | 58 |
| NUP98-TOP1 | AML (mean latency, 233 d) | BMT | 59 |
| NUP98-TOP1 and Meis1 | AML (mean latency, 242 d) | BMT | 59 |
| NUP98-NSD1 | AML (mean latency, 126 d) | BMT | 39 |
| NUP98-JARID1A | AML (mean latency, 69 d) | BMT | 47 |
BMT indicates retroviral bone marrow transduction.