Table 6.
Personal history of autoimmune diseases and risk of MGUS with more than 5 years' latency
| Category or condition | MGUS patients (n = 5403) | MGUS controls (n = 21 209) | OR* (95% CI) [P] |
|---|---|---|---|
| Total autoimmune disease | 247 | 499 | 2.0 (1.7-2.3) |
| Autoantibodies detectable | 156 | 313 | 2.0 (1.6-2.4) |
| Systemic involvement | 106 | 189 | 2.2 (1.7-2.8) |
| Rheumatoid arthritis | 84 | 155 | 2.1 (1.6-2.8) |
| Systemic sclerosis | 3 | 3 | 3.9 (0.8-19.5) |
| Sjögren syndrome | 4 | 6 | 2.6 (0.7-9.3) |
| Organ involvement | 55 | 134 | 1.6 (1.2-2.2) |
| Pernicious anemia | 9 | 20 | 1.8 (0.8-3.8) |
| Autoimmune hemolytic anemia | 1 | 0 | ∞ [.20] |
| Immune thrombocytopenia | 5 | 2 | 9.9 (1.9-51.2) |
| Polyarteritis nodosa | 3 | 0 | ∞ [< .05] |
| Guillain-Barré syndrome | 3 | 4 | 3.0 (0.7-13.2) |
| Celiac disease | 3 | 5 | 2.4 (0.6-10.0) |
| Chronic rheumatic heart disease | 14 | 35 | 1.6 (0.9-2.92) |
| Autoantibodies not detectable | 110 | 215 | 2.0 (1.6-2.6) |
| Ankylosing spondylitis | 12 | 17 | 2.8 (1.3-5.9) |
| Polymyalgia rheumatica | 30 | 36 | 3.3 (2.0-5.3) |
| Giant cell arteritis | 10 | 2 | 19.5 (4.3-89.2) |
| Aplastic anemia | 3 | 0 | ∞ [< .05] |
*
When no case patient or control subject has the specific condition, P values (2-sided) based on Fisher exact test are given.