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Loss of one bcl-x allele significantly delays Εμ-myc lymphoma development. Kaplan-Meier analysis of tumor development comparing control Εμ-myc transgenic mice with Εμ-myc/bcl-2+/− and Εμ-myc/bcl-x+/− mice. Median tumor onset was 116 days for Εμ-myc, 154 days for Εμ-myc/bcl-2+/− (P = .303) and 174 days for Εμ-myc/bcl-x+/− mice (P = .023).
