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. 2011 Dec 12;6(12):e28388. doi: 10.1371/journal.pone.0028388

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Halachev et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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We define HCBOs (Highly Conserved Bacterial Orthologs) as CDSs that is present in at least 90% of the considered bacterial genomes. The COG functional assignment was performed using COGnitor.