Table 3. PrPSc distribution in nasal cavity and olfactory bulb.
| Olfactory sensory epithelium | Subepithelium1 | Olfactory bulb2 | ||||||||
| Hamster | Cell body | Dendrite | Knob | Nerve bundle | NALT | ONL | GL | OPL | M | IPL |
| H1470.2 | 0.93 | 0.0 | 2.1 | 0.0 | 0.0 | nd | nd | nd | nd | nd |
| H1470.3 | 0.0 | 0.0 | 0.9 | 0.1 | 0.0 | 0.0 | 0.9 | 0.3 | 0.0 | 0.0 |
| H1471.2 | 0.6 | 0.0 | 1.6 | 0.0 | 0.0 | 0.0 | 0.8 | 0.5 | 0.0 | 0.0 |
| H1471.3 | 0.3 | 0.0 | 1.2 | 0.0 | 0.0 | 0.0 | 1.1 | 0.5 | 0.0 | 0.0 |
| H1472.1 | 1.4 | 0.2 | 2.9 | 0.5 | 0.0 | 0.0 | 3.0 | 2.2 | 0.0 | 0.0 |
| H1472.3 | 0.5 | 0.0 | 1.5 | 0.0 | 0.0 | 0.0 | 0.7 | 0.8 | 0.4 | 0.0 |
| Average: | 0.6 | <0.1 | 1.7 | <0.1 | 0.0 | 0.0 | 1.3 | 0.8 | <0.1 | 0.0 |
| SEM: | 0.2 | <0.0 | 0.3 | <0.1 | 0.0 | 0.0 | 0.5 | 0.3 | <0.1 | 0.0 |
1
Subepithelium of nasal mucosa; NALT, nasal-associated lymphoid tissue.
2
Olfactory bulb structures include the ONL, outer nerve layer; GL, glomerular layer; OPL, outer plexiform layer, M, mitral layer; IPL, inner plexiform layer.
3
The relative intensity of PrPSc deposition in the hamster brain infected with CWD was scored on a 0 to 3 scale with 0 = no immunoreactivity, 1 = mild immunoreactivity, 2 = moderate immunoreactivity, and 3 = intense immunoreactivity. For each hamster a minimum of twenty-four tissue sections were examined spanning the middle to posterior portion of the nasal cavity.
nd, not done.