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. 2011 Dec 12;6(12):e28887. doi: 10.1371/journal.pone.0028887

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Lim et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Treatment of SH-SY5Y human neuroblastoma cells with Aβ42 causes decreased levels of estradiol, indicative of an impairment of ABAD activity, while HA does not. Results are means ± SE, (n = 5 to 6 per group), **, P<0.01 (B) Pull-down of ABAD from SH-SY5Y cells shows that different from HA, Aβ42 can bind to ABAD in vitro. (C) Structure of the ABAD inhibitor, AG18051 (adapted from Kissinger et al., JMB 2004).