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. 2011 Dec 12;6(12):e28887. doi: 10.1371/journal.pone.0028887

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Lim et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Aβ causes reduced cellular (DCF) as well as mitochondrial ROS (DHR), e.g. reduced mitochondrial superoxide anion radicals (DHE). Levels are restored to vehicle upon pre-treatment with AG18051, irrespective of whether the SH-SY5Y cells have been incubated with Aβ or HA. *, P<0.05; ***, P<0.001.