Figure 8. The ABAD inhibitor AG18051 partially prevents the toxicity of HA, but not its metabolic impairment.

(A) Co-incubation of HA with AG18051 partially maintains levels of LDH release in SH-SY5Y cells suggesting that the toxicity of HA is partially mediated by ABAD. (B) Treatment with 0.5 µM HA significantly decreases metabolic activity as shown with the MTT assay, which is not prevented with co-incubation with AG18051. *, P<0.05; **, P<0.01.