Figure 3. Effect of postnatal proteasome inhibition on exploratory activity in adult mice.

A Total motor activity of mice treated with the vehicle alone, MG132 and lactacystin (black, gray and white symbols, respectively), as measured in an open field for 5 minutes. B Minute-by minute evolution of motor activity over 5 minutes in the same experimental animals. The habituation index was determined as the ratio between the activity in the last and the first minute in the open field. n = 15, 10 and 10 in control, MG132, and lactacystin treated groups, respectively. **, p<0.01; ***, p<0.001.