Fig. 2.

K ^trans map (a) derived from DCE MRI of rabbit brain 3 days after weight drop induced traumatic brain injury [42]. BBB permeability is increased in focal and perifocal lesion areas as compared to contralateral. Graphs (b) show K ^trans in different brain areas over time after traumatic brain injury or sham injury. In the focal lesion area (top graph), K ^trans was consistently higher than in comparable brain regions of sham-operated animals from 3 h up to 30 days after traumatic brain injury, peaking around day 3. In the perifocal area (middle graph), K ^trans was higher at 1, 3 and 7 days post-trauma, as compared to the sham group. In contralateral brain tissue (bottom graph), K ^trans was similar in the traumatic brain injury and sham injury groups at all time-points. Exact details of the location and size of the regions-of-interest are described by Wei et al. [42]. Data represent mean ± SD. ^* P < 0.01 as compared to the sham group. The publisher for part of this copyrighted material is Mary Ann Liebert, Inc. publishers (Courtesy of Dr. Xiao-Er Wei)