Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Aug 16;13(4):R81. doi: 10.1186/bcr2933

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright ©2011 Gould et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Mcs5a allele is associated with increased concanavalin A (conA)-induced Th1 cytokine production and proliferation. (a) Interleukin-2 (IL-2), interferon-gamma (IFNγ), or tumor necrosis factor (TNF) concentrations (in picograms per milliliter) in the media produced by cultured T cells from spleens of susceptible congenic control (susc., open bars; -DMBA n = 30, +DMBA n = 8) and Mcs5a congenic resistant (Mcs5a, filled bars; -DMBA n = 30, +DMBA n = 8) rats without or with conA stimulation. (b) IL-2, IFNγ, or TNF concentrations (in picograms per milliliter) in the media produced by cultured T cells from inguinal mammary lymph nodes (LNs) of susceptible congenic control (open bars; -DMBA n = 8, +DMBA n = 8) and Mcs5a congenic resistant (filled bars; -DMBA n = 8, +DMBA n = 8) rats without or with conA stimulation. (c) IL-4, IL-6, or IL-17 concentrations (in picograms per milliliter) in the media produced by cultured T cells from spleens of susceptible congenic control (open bars, n = 22) and Mcs5a congenic resistant (filled bars, n = 22) rats without or with conA stimulation. (d) Percentage of second- and later-generation daughter cells among CD4⁺, CD8⁺, and γδTCR⁺T cells from susceptible congenic control (open bars, n = 24) and Mcs5a-resistant congenic (filled bars, n = 26) rats without or with conA stimulation. Significantly different (P < 0.05) cytokine production or proliferation between susceptible congenic control and Mcs5a-resistant congenic rat lines is indicated by an asterisk. Values are expressed as average ± standard error of the mean. DMBA, 7,12-dimethylbenz(a)anthracene; Mcs5a, mammary carcinoma susceptibility locus 5a; TCR, T-cell receptor.