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ASC Effector Mechanisms. ASC is involved in innate and adaptive immune responses. ASC modulates inflammation, cell survival, cell death, chemokine activation, lymphocyte chemotaxis, and antigen uptake and presentation. Other functions of ASC have also been revealed that are independent of an inflammasome complex, including regulation of the NF-κB pathway and MAPK activation as well as controlling the stability of Dock2 mRNA.
