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. 2011 Dec 13;2:78. doi: 10.3389/fphar.2011.00078

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Copyright © 2011 Kaczorowski, Garcia, Bode, Hess and Patel.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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(A) Activity of 10 μM BIRB0796 on cardiac ion channels within Millipore’s Safety and Liability Panel. (B) Because of the significant inhibition observed at 10 μM, full concentration response curves for hERG and Kv1.5 were carried out with BIRB0796. Calculated IC₅₀ values were 2.3 and 1.1 μM for hERG and Kv1.5, respectively.