Table 1.
Activity expressed as percentage inhibition of 10 μM BIRB0796 on 39 kinases and 2 phosphatases within Millipore’s Safety and Liability Panel.
| Kinase/phosphatase | Percentage inhibition |
|---|---|
| Abl(h) | 80 |
| AMPK(r) | 1 |
| CaMKIIβ(h) | 22 |
| CaMKIIγ(h) | 11 |
| CaMKII(δ(h) | 22 |
| CDK1/cyclinB(h) | −6 |
| CDK2/cyclinA(h) | −6 |
| CDK2/cyclinE(h) | −11 |
| CDK3/cyclinE(h) | −10 |
| CDK5/p25(h) | 1 |
| CDK5/p35(h) | −26 |
| CDK7/cyclinH/MAT1(h) | 17 |
| CDK9/cyclin T1(h) | −17 |
| Flt1(h) | 96 |
| GSK3β(h) | −6 |
| IR(h) | −3 |
| LKB1(h) | 10 |
| Lyn(h) | 81 |
| MAPK1(h) | −3 |
| MAPK2(h) | −10 |
| p70S6K(h) | 39 |
| PhKγ2(h) | −1 |
| PKA(h) | 6 |
| PKBβ(h) | −15 |
| PKCμ(h) | 13 |
| PKCα(h) | 9 |
| PKCβI(h) | −17 |
| PKCβII(h) | −11 |
| PKCγ(h) | 7 |
| PKCδ(h) | −15 |
| PKCε(h) | 16 |
| PKCζ(h) | −3 |
| PKCη(h) | −14 |
| PKCθ(h) | −29 |
| PKC℩(h) | 3 |
| PKG1α(h) | 15 |
| PKG1β(h) | 13 |
| ROCK-II(h) | −3 |
| SAPK2a(h) | 94 |
| PTP1B(h) | 18 |
| TCPTP(h) | 17 |
The 39 kinases are arranged alphabetically from Abl (top) to SAPK2a (near bottom). The two phosphatases are PTP1B and TCPTP. Except for the rat AMPK, all enzymes and phosphatases were the human form. Red font is used to highlight the targets where the inhibition observed was >50%.