Table 3.

Potency values for reference Nav inhibitors as determined with the 2-pulse protocol.

Reference compound	Predicted IC50 potency values (μM)
	Nav1.2		Nav1.5		Nav1.6
	P1	P2	P1	P2	P1	P2
Lidocaine	–	8.2	–	4	270	4.7
Tetracaine	18	0.12	19	0.17	9.4	0.08
Lamotrigine	–	8.6	–	8.8	–	5.2
Carbamazepine	–	12	–	5.7	–	4.6
Flecainide	11	3.2	9.1	3	9.7	2.7
Phenytoin	–	5.8	–	6.5	–	7
Riluzole	38	4.7	39	0.77	32	1.4

See Figure 4 for the protocol.