Table 1.
Risk of neonatal morbiditya according to preterm birth and maternal use of CNS-active drugsb after the first trimester (both 2nd and 3rd trimester). Among all infants, 6.0% were born preterm, and among infants of women using CNS-active drugs, 8.2% were born preterm.
| Infant group | With neonatal pathology | Total number | % | OR | 95% CI |
|---|---|---|---|---|---|
| All infants | 22015 | 315975 | 7.0 | 1.00 | Reference |
| Preterm births | 7465 | 18836 | 39.6 | 12.3 | 12.0–12.7 |
| CNS-active drugs, all infants | 541 | 4425 | 12.2 | 1.83 | 1.67–2.00 |
| CNS-active drugs, term infants | 380 | 4009 | 9.5 | 2.05 | 1.84–2.28 |
a Infant morbidity consists of one or more of the following conditions: respiratory disorders (ICD-10 codes P22–P28), hypoglycaemia (P70.4–P70.9), neonatal convulsions (P90), other disturbances of cerebral status (P91), low Apgar score (Apgar 5 minutes <7).
b The drugs studies include opioids, anticonvulsants, antipsychotics, sedative/hypnotics, and antidepressants.