Table 2.

Early pharmacotherapies for NVP/HG.

First-line therapy:

Pyridoxine hydrochloride monotherapy 10–25 mg po tid-qid

-or-Pyridoxine hydrochloride 10–25 mg po tid or qid plus Doxylamine succinate 25 mg 1/2 tablet po tid-qid

-or-Diclectin (pyridoxine hydrochloride 10 mg plus doxylamine succinate 10 mg) 4 tablets qd given 1 qam, 1 at lunch, and 2 qhs with a maximum of 8–12 tablets qd if increased BMI

Breakthrough therapy:

Dimenhydrinate 50–100 mg po/iv q 4–6 hours

Promethazine 12.5–25 mg po/iv/pr q 4–6 hours

Metoclopramide 5–10 mg po/iv tid

Ondansetron 4–8 mg iv/po tid