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. 2011 Dec 11;2011:840194. doi: 10.1155/2011/840194

Figure 4.

Figure 4

Influence of PPAR antagonists on RXR agonist and PPARγ agonist-induced anti-inflammatory effects. NEt-3IP was orally administrated 3 h before carrageenan injection at a dose of 10 mg/kg. Nonselective PPAR antagonist, BADGE was injected intraperitoneal 30 min before carrageenan injection at doses of 10 and 30 mg/kg. PPARα antagonist, GW6471 was injected into subplantar 15 min before carrageenan injection at doses of 10 and 30 μg/paw. PPARγ antagonist, GW9662 was injected into subplantar 15 min before carrageenan injection at doses of 3 and 10 μg/paw. PPARδ antagonist, JKPL-85 was injected into subplantar 15 min before carrageenan injection at doses of 10 and 30 μg/paw. The vehicle group received physiological saline including 10% dimethylsulphoxide. Each column and vertical bar represents the means ± S.E.M. (n = 7). **: Significantly different from the control group at P < 0.01 (Dunnett's test). †,††: Significantly different from the vehicle group at P < 0.05 and P < 0.01, respectively (Dunnett's test).