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. 2011 Nov 24;2011:467180. doi: 10.1155/2011/467180

Figure 4.

Figure 4

Neuronal demise in Alzheimer's disease. The pathologic interaction of cerebral Aβ with transition metals induces oxidative stress, perturbed cellular Ca2+ homeostasis, and energy metabolism, which in turns generates more ROS leading to neuronal demise.