Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Nrf2 regulates the expression of antioxidant enzymes. Under physiological conditions, Nrf2 binds to Keap1 and undergoes constitutive proteasome-dependent degradation. However, under oxidative stress, Keap1 changes its conformation and releases Nrf2, which moves to the nucleus and binds to ARE regulating the expression of several antioxidant enzymes.
