Table 1. Demographic and clinical data relating to atopic dermatitis cases and unselected population controls.

	Irish pediatric atopic dermatitis cases		Irish population controls
	Genotyped collection (n=876)	Filaggrin (FLG) mutation carriers excluded (n=528)	Genotyped collection (n=928)	FLG mutation carriers excluded (n=824)
Male sex, number (%)	545 (62.2)	332 (62.9)	278 (30.0)	251 (30.5)
Mean age, years (SD)	3.3 (3.5)	3.0 (3.3)	36.2 (12.4)	36.2 (12.5)
Nottingham eczema severity score, mean (SD)	11.2 (2.6)	11.0 (2.5)	Not known	Not known

The diagnosis of atopic dermatitis was made by experienced dermatologists according to the United Kingdom diagnostic criteria (Williams et al., 1994) with disease severity scored according to the Nottingham Eczema Severity Score, in which 1 to 8 denotes mild atopic dermatitis, 9 to 11 is moderate, and 12 to 15 defines severe disease (Emerson et al., 2000). The control population represents consecutive successfully genotyped Trinity Biobank Control samples, derived from Irish adult blood donors.