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Antitumor efficacy of different weight loadings of IT-141 in an HT-29 xenograft model. IT-141 was formulated to contain either 4 or 11% SN-38 by weight and was administered i.v. to nude mice bearing HT-29 tumors at 5, 15, or 30 mg/kg. Each group contained six mice. Arrows indicate days of injection (days 0, 4, and 8). Data are presented as mean tumor volume ± standard error.
