Table 1.
IC50 values (μM) of IT-141 compared to free SN-38 and irinotecan in cancer cell lines. Data are presented as mean ± standard deviation.
| Cell line | IT-141 (μM) | Free SN-38 (μM) | Irinotecan (μM) | |
|---|---|---|---|---|
| Colon | HT-29 | 0.0374 ± .001 | 0.0452 ± .002 | 24.6 ± 6.4 |
| HCT-116 | 0.165 ± .021 | 0.133 ± .037 | 16.3 ± 1.3 | |
| Prostate | PC-3 | >5.0 | >5.0 | >100 |
| LNCaP | 0.081 ± 0.006 | 0.083 ± 0.008 | 10.7 ± 2.2 | |
| Osteosarcoma | MG-63 | 0.080 ± 0.004 | 0.076 ± 0.002 | 7.2 ± 0.9 |
| Pancreatic | BxPC-3 | 0.072 ± 0.004 | 0.072 ± 0.002 | 6.5 ± 1.3 |
| Breast | MDA-MB-453 | 0.679 ± 0.006 | 0.661 ± 0.038 | >100 |
| MDA-MB-231 | >1.0 | >1.0 | 66.3 ± 6.0 | |
| MCF-7 | 0.717 ± 0.141 | 0.529 ± 0.017 | 86.0 ± 4.6 | |
| BT-474 | >3.0 | >3.0 | >200 | |
| Lung | A549 | 0.091 ± 0.002 | 0.099 ± 0.001 | 7.7 ± 1.0 |