Table III.

Sex differences in brain activations during stress and alcohol‐cue exposures

			Sex × task					Stress‐neutral					Alcohol cue‐neutral
			Coordinates					Coordinates					Coordinates
								X	Y	Z			X	Y	Z
Regions of activation	Lat	BA	X	Y	Z	Volume (mm3)	F	Male > Female			Volume (mm3)	t	Female > Male			Volume (mm3)	t
Superior/middle frontal gyrus	L	6	−19	−8	65	2,056	5.98	—	—	—	—	—	−15	−12	62	2,704	2.33
Medial frontal gyrus	B	9, 10	−1	48	21	1,595	5.63	2	46	23	6,878	2.5	—	—	—	—	—
Rostral anterior cingulate gyrus	B	32	6	39	16	1,051	5.79	4	40	14	2,667	2.4	—	—	—	—	—
Posterior insula	L	—	−42	−6	−7	422	5.54	−37	−6	−9	641	2.26	—	—	—	—	—
	R	—	43	6	−4	3,432	6.04	40	7	−13	1,381	2.24	—	—	—	—	—
Amygdala	L	—	−23	−1	−15	906	5.66	−23	−3	−17	1,803	2.53	—	—	—	—	—
	R	—	27	−3	−14	633	5.51	26	−2	−17	1,780	2.41	—	—	—	—	—
Hippocampus	L	—	−29	−22	−13	919	5.47	−28	−19	−16	3,095	2.5	—	—	—	—	—
	R	—	24	−15	−15	408	5.38	28	−16	−16	1,957	2.46	—	—	—	—	—
Parahippocampal gyrus	R	—	22	−21	−16	166	5.35	21	−29	−14	1,774	2.39	—	—	—	—	—
Putamen	L	—	−24	7	−11	387	5.78	−25	4	−9	796	2.29	—	—	—	—	—
Superior/middle TG	L	21, 22, 38	−44	0	−18	992	5.92	−36	1	−28	1,989	2.26	—	—	—	—	—
Superior/middle/inferior TG	R	20, 21, 22, 37, 39	50	−38	−4	8,061	6.29	52	−43	−4	24,088	2.47	—	—	—	—	—
Superior parietal lobe	B	7	12	−66	55	4,372	5.88	8	−62	51	10,384	2.46	—	—	—	—	—
Lingual gyrus (occipital lobe)	L	19	−14	−54	−2	1,340	5.81	−15	−55	0	3,085	2.46	—	—	—	—	—
Cerebellum	B	—	17	−53	−19	4,058	6.06	10	−52	−21	7,688	2.47	—	—	—	—	—

Whole‐brain FWE corrected thresholds at P < 0.01 for Sex × Task and at P < 0.05 for Stress > Neutral and Alcohol Cue > Neutral. Lat, laterality; B, bilateral; L, left; R, right; BA, Brodmann's area; TG, temporal gyrus. No differences in female > male for the Stress‐Neutral and in male > female for the Alcohol Cue‐Neutral survived FWE correction.