Table 4.

Prevalence of HPV in intraepithelial neoplasia and carcinoma of the vulva, by study.

Histologic type	First author	No. of cases	HPV test	HPV prevalence for any and specific genotypes
VIN I
	Smith (review)	71	PCR/hybrid capture assays	Any HPV, 77.5% Most common types; 6 (23.8%), 16 (14.3%), 56 (1.7%)
	De Vuyst (meta-analysis)	90	PGMY reverse line blot/SPF 10 line probe assay	Any HPV, 67.8% Most common types; 6 (22.4%), 16 (9.8%), 11 (9.0%)
	Garland (original article)	31	Reverse line blot assay	Any HPV, 80.6% Most common types; 6 or 11 (64.5%)
VIN II/III
	Smith	1340	PCR/hybrid capture assays	Any HPV, 80.4% Most common types; 16 (71.2%), 33 (7.7%)
	De Vuyst	1061	PGMY reverse line blot/SPF 10 line probe assay, sequencing, southern hybridization, restriction fragment-length polymorphism analysis	Any HPV, 85.3% Most common types; 16 (71.9%), 33 (8.0%),18 (5.0%)
	Garland	31	Reverse line blot assay	Any HPV, 87.1% Most common types; 16 (64.5%), 6, or HPV11 (29%)
Vulvar SCC
	Smith	1379	PCR/hybrid capture assays	Any HPV, 40.1% Most common types; 16 (29.3%), 18 (5.6%)
	De Vuyst	1873	Reverse line blot hybridization, dot blot hybridization, Roche HPV linear array	Any HPV, 40.4% Most common HPV types; 16 (32.2%), 33 (4.5%), 18 (4.4%)