Table 1.
Baseline demographic characteristics of the intention-to-treat (ITT) and the per-protocol (PP) populations
| Characteristic | Relaxation (n = 30) | Exercise (n = 30) | Topiramate (n = 31) | Total ITT (n = 91) | Total PP (n = 72) |
|---|---|---|---|---|---|
| Age (years) | 41.5 ± 11. 4 | 47.0 ± 10.8 | 44.4 ± 9.2 | 44.3 ± 10.6 | 44.4 ± 11.3 |
| Sex | |||||
| Male | 2 (7) | 5 (17) | 2 (6) | 9 (10) | 6 (8) |
| Female | 28 (93) | 25 (83) | 29 (94) | 82 (90) | 66 (92) |
| Weight (kg) | 69.8 ± 9.8 | 70.1 ± 13.3 | 75.6 ± 15.0 | 72.1 ± 13.0 | 72.1 ± 12.7 |
| Height (cm) | 170 ± 6.5 | 170 ± 8.4 | 170 ± 6.4 | 170 ± 7.1 | 170 ± 6.4 |
| Body mass index (kg/m2) | 24.1 ± 2.3 | 24.9 ± 4.1 | 26.4 ± 4.8 | 25.1 ± 3.9 | 25.1 ± 3.9 |
| Smoking | 1 (3) | 2 (7) | 3 (10) | 6 (7) | 5 (7) |
| Type of migraine | |||||
| Migraine with aura | 1 (3) | 3 (10) | 3 (10) | 7 (8) | 5 (7) |
| Migraine without aura | 16 (53) | 11 (37) | 17 (35) | 44 (48) | 34 (47) |
| Migraine with and without aura | 13 (43) | 16 (53) | 11 (55) | 40 (44) | 33 (46) |
| Duration of disease (years) | 22.2 ± 11.8 | 28.8 ± 11.0 | 25.1 ± 11.4 | 25.4 ± 11.6 | 25.7 ± 11.9 |
| Baseline frequency of migraine (days) | 7.6 ± 3.8 | 7.0 ± 3.8 | 7.5 ± 3.9 | 7.3 ± 3.8 | 7.2 ± 3.6 |
| Baseline frequency of migraine attacks (numbers of attacks) | 4.2 ± 1.6 | 4.3 ± 2.0 | 3.6 ± 1.6 | 4.0 ± 1.8 | 4.1 ± 1.7 |
| Baseline frequency of headache medication used (doses) | 6.5 ± 4.6 | 6.9 ± 4.1 | 7.1 ± 5.3 | 6.8 ± 4.6 | 7.4 ± 4.8 |
| Baseline intensity of pain (VAS) | 39 (26–55) | 50 (26–64) | 40 (29–58) | 40 (29–61) | 45 (30–63) |
| Baseline MSQoL | 58 (51–67) | 60 (43–77) | 60 (48–73) | 60 (47–72) | 59 (50–71) |
| Baseline oxygen uptake (ml x kg−1 x min−1) | 34.9 ± 2.4 | 33.8 ± 1.7 | 30.9 ± 2.1 | 33.2 ± 1.2 | 32.7 ± 1.1 |
Data are expressed as number (%), mean±standard deviation or median (interquartile range). MSQoL = Migraine-specific quality of life; VAS, visual-analogue scale.