Figure 7.

Effects of treatment with the strong pan-PLA₂ inhibitor (FKGK2) on locomotor and histological changes after SCI. A) Locomotor recovery evaluated using the BMS analysis shows that FKGK2-treated mice have markedly poor locomotor recovery starting as early as 7 d after SCI. B) The finer aspects of locomotor control assessed with the BMS subscore analysis also showed worse outcome in mice treated with FKGK2 at 28 d after SCI. C–F) Mice treated with FKGK2 also showed significantly less tissue sparing (C), less neuronal survival (D), less spared myelin at and adjacent to the epicenter (E), and no difference in serotonergic innervation (F) at 1000 μm caudal to the lesion. n = 9/group. *P < 0.05.