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. Author manuscript; available in PMC: 2012 Aug 15.
Published in final edited form as: Cancer. 2011 Feb 8;117(16):3691–3702. doi: 10.1002/cncr.25861

Figure 6.

Figure 6

Changes of the expression patterns of TGFβ and Notch signaling components in switch from normal esophagus to adenocarcinoma. A. Different layers of normal esophagus are shown with corresponding expression patterns of Hes1, Oct3/4, Smad4, β2SP and RUNX3. B. Loss of normal hierarchy of esophageal epithelium in adenocarcinoma. Hes1, oct3/4, Smad4, β2SP and RUNX3 are not expressed in gradients as in normal tissue. While expression of Hes1, oct3/4 and SOXs proteins is increased, the expression of Smad4, β2SP and RUNX3 are decreased compared to normal tissue. C. Model of the interaction between notch and TGFβ signaling pathways in maintaining the hierarchy of esophagus epithelium.