Table 1.

Summary of Patient Cohorts

Cohort	Source Institution	Tumor Type	Sample Type	No. of Patients	Ratio of Males to Females	No. ofIDH1R132MUT Tumors	Mean Age(years)	Range of Ages(years)	Figure	Reference
A	UCLA, KPLA	Primary GBM	Newly diagnosed*	389	1.5	19	56.8	24–90	1A-B, 2A, 3A-C, 4A; Appendix A1A-A1C, A2B,A3D-A3E, A4A-A4C	N/A
B	MDACC	Primary GBM	Newly diagnosed	70	1.7	8	54.6	20–80	1A, 2A, 3A, 3C, 4A; Appendix A1A, A3E, A4A, A4C	N/A
C	UCSF, MDACC	Primary GBM	Newly diagnosed*	98	1.7	22	46.3	19–82	2A-B, 3A, 3C, 4A; Appendix A1A, A3E, A4A	Phillips et al17
D	UCSF	Primary GBM	Newly diagnosed	29	1.9	0	56.0	27–76	2A, 3A, 3C, 4A; Appendix A3E, A4A	Chen et al18
E	UCSF, MDACC	Primary GBM	Newly diagnosed	14	N/D	0	11.7	2–17	3A, 3C; Appendix A4A	Schiffman et al19†
F	UKE	Primary GBM	Newly diagnosed*	18	1.3	0	65.3	32–85	2A, 3A, 3C, 4A; Appendix A1A, A3E, A4A	Günther et al20†
G	UCSF, MDACC	AA	Newly diagnosed	77	1.3	42	38.5	7–75	2A, 3C, 4A; Appendix A2A-A2B, A3E, A4A	Phillips et al17†
H	UCLA, KPLA	Grades II and III diffuse glioma	Newly diagnosed	158	1.1	103	40.1	15–79	3C, 4A; Appendix A3A-A3C, A3E	N/A
I	Various	Grades II to IV diffuse glioma	Newly diagnosed and recurrent	105	N/D	37	N/D		4A	N/A

NOTE. Samples from newly diagnosed patients were obtained before treatment. Tumor type is according to WHO criteria.

Abbreviations: AA, anaplastic astrocytoma; GBM, glioblastoma; IDH1^R132MUT, mutation in isocitrate dehydrogenase 1 (IDH1) at R132; KPLA, Kaiser Permanente Los Angeles; MDACC, MD Anderson Cancer Center; N/A, not applicable; N/D, not done; UCLA, University of California at Los Angeles; UCSF, University of California at San Francisco; UKE, Universitätsklinikum Hamburg-Eppendorf.

^*Includes matched recurrent specimens for a subset of cases.

^†Cohort includes additional specimens not described in original publication.