Table 2.
Disease-Specific Survival According to Clinicopathologic Variables in Univariate and Multivariate Analysis Among Never Smokers (n = 236)
| Clinicopathologic Variable | Univariate |
Multivariate* |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Sex | ||||||
| Male | 1.57 | 1.00 to 2.47 | .049 | 1.25 | 0.76 to 2.05 | .370 |
| Female | Ref | Ref | ||||
| Age, per year increase | 1.00 | 0.99 to 1.02 | .841 | 1.01 | 0.99 to 1.02 | .378 |
| Stage | ||||||
| IIIC | 14.16 | 6.73 to 29.81 | < .0001 | 11.98 | 5.60 to 25.63 | < .0001 |
| IIIB | 10.55 | 5.11 to 21.79 | < .0001 | 11.19 | 5.32 to 23.54 | < .0001 |
| IIIA | 7.96 | 3.81 to 16.64 | < .0001 | 7.57 | 3.59 to 15.98 | < .0001 |
| IIB | 3.96 | 1.80 to 8.30 | .0003 | 4.12 | 1.96 to 8.66 | .0002 |
| IA to IIA | Ref | Ref | ||||
| Grade | ||||||
| 4 | 1.61 | 1.17 to 2.22 | .0038 | 1.17 | 0.83 to 1.65 | .374 |
| 1 to 3 | Ref | Ref | ||||
| Weight loss in the year preceding surgery | ||||||
| ≥ 10% | 1.68 | 1.19 to 2.38 | .0035 | 1.38 | 0.96 to 1.99 | .081 |
| < 10% | Ref | Ref | ||||
| Body mass index | ||||||
| Obese | 1.62 | 1.03 to 2.53 | .034 | 2.11 | 1.31 to 3.43 | .0023 |
| Overweight | 1.17 | 0.81 to 1.71 | .403 | 1.27 | 0.86 to 1.88 | .231 |
| Normal | Ref | Ref | ||||
Abbreviations: HR, hazard ratio; Ref, reference (HR = 1.0).
*
Adjusted for all variables shown in table.