Figure 2. Hamster weight as an end-point for leptospiral infection.

Animals were weighed at the time of challenge and daily thereafter for 28 days. Data are shown for experiment #2. A. Animals immunized with recombinant LigA7′-13 progressively gained weight (lines represent individual animals). B. Control animals sham-immunized with phosphate-buffered saline (PBS) had stable or increasing weights until day 8 or 9 after challenge, after which they lost weight and met the end-point criterion of a 10% weight decrease (lines represent individual animals).