Table 2. Summary of immunoprotection outcomes^a.

Immunogen(LigA Domains)	Survivalb(%)	MAT(Positives/Total)	Culturec(Positives/Total)	Histologyc(Mean Score)	qPCRc,d(Log10)
Experiment 1
7′-13	100	3/3	4/4	ND	5.79±2.0
7′-9	0*	1/3	4/4	ND	3.92±0.3
7′-11	50	2/4	2/4	ND	3.10**±0.8
10-13	100	4/4	4/4	ND	5.92±0.8
12-13	50	0/4	4/4	ND	5.53±1.3
HKL	100	3/3	0/4	ND	2.48**±0.6
PBS	0*	0/1	4/4	ND	4.66±1.0
Experiment 2
7′-13	100	4/4	4/4	1.0	4.13±0.2
10-13	100	4/4	4/4	2.5	4.90±1.0
10-12	100	4/4	4/4	3.3**	4.81±0.4
11-13	100	4/4	4/4	1.75	5.61±1.2
11-12	25	4/4	1/4	3.3**	4.29±0.8
HKL	100	3/4	0/4	1.25	2.39**±0.2
PBS	0*	3/3	2/4	ND	2.72**± 0.2

^aAbbreviations: HKL  =  heat-killed leptospires, PBS  =  phosphate-buffered saline, ND  =  not done.

^bFour animals per group. *Statistically different from the LigA7′-13 group (Fisher's exact test, P<0.05).

^cData refer to kidney analysis. Means are shown for Histology and qPCR (n = 4).

**Statistically different from the LigA7′-13 group (ANOVA, Dunn post-test, P<0.05).

^dExpressed as copies per microgram of tissue DNA.