Table 1. List of over-represented GO terms in gene groups with distinct lifecycle stage dependent transcriptional patterns.
| MICRO-FILARIAL | LATE LARVAL | MALE | FEMALE/EGGS | GO terms | |
| cellular component | |||||
| 1.8E-22 | intracellular | GO:0005622 | |||
| 1.2E-05 | integral to membrane | GO:0016021 | |||
| 2.1E-04 | membrane | GO:0016020 | |||
| 2.9E-04 | intermediate filament | GO:0005882 | |||
| 7.8E-05 | cytoskeleton | GO:0005856 | |||
| 6.2E-07 | nucleus | GO:0005634 | |||
| molecular function | |||||
| 1.2E-23 | zinc ion binding | GO:0008270 | |||
| 1.4E-10 | nucleic acid binding | GO:0003676 | |||
| 9.7E-06 | chitinase activity | GO:0004568 | |||
| 1.6E-05 | cation binding | GO:0043169 | |||
| 2.5E-05 | hydrolase activity, acting on glycosyl bonds | GO:0016798 | |||
| 2.5E-05 | 1.8E-06 | cysteine-type peptidase activity | GO:0008234 | ||
| 7.6E-04 | hydrolase activity, hydrolyzing O-glycosyl compounds | GO:0004553 | |||
| 9.2E-10 | 1.8E-06 | structural constituent of cuticle | GO:0042302 | ||
| 2.9E-06 | cysteine-type endopeptidase activity | GO:0004197 | |||
| 1.6E-05 | transporter activity | GO:0005215 | |||
| 3.3E-05 | oxidoreductase activity | GO:0016491 | |||
| 4.5E-05 | extracellular matrix structural constituent | GO:0005201 | |||
| 9.5E-05 | 3.8E-04 | serine-type endopeptidase inhibitor activity | GO:0004867 | ||
| 1.2E-04 | voltage-gated chloride channel activity | GO:0005247 | |||
| 4.7E-04 | calcium ion binding | GO:0005509 | |||
| 8.8E-04 | hedgehog receptor activity | GO:0008158 | |||
| 9.5E-18 | phosphoprotein phosphatase activity | GO:0004721 | |||
| 1.1E-13 | protein kinase activity | GO:0004672 | |||
| 6.7E-12 | structural molecule activity | GO:0005198 | |||
| 6.3E-10 | kinase activity | GO:0016301 | |||
| 2.8E-08 | protein tyrosine phosphatase activity | GO:0004725 | |||
| 1.0E-06 | protein tyrosine kinase activity | GO:0004713 | |||
| 5.7E-06 | phosphatase activity | GO:0016791 | |||
| 5.8E-04 | ATP binding | GO:0005524 | |||
| 1.6E-11 | transcription factor activity | GO:0003700 | |||
| 5.5E-10 | sequence-specific DNA binding | GO:0043565 | |||
| 4.4E-07 | DNA binding | GO:0003677 | |||
| 6.1E-05 | ligand-dependent nuclear receptor activity | GO:0004879 | |||
| 1.0E-04 | transcription regulator activity | GO:0030528 | |||
| biological process | |||||
| 1.0E-04 | 1.9E-04 | proteolysis | GO:0006508 | ||
| 6.2E-04 | chitin catabolic process | GO:0006032 | |||
| 1.4E-06 | metabolic process | GO:0008152 | |||
| 6.0E-06 | oxidation reduction | GO:0055114 | |||
| 4.0E-05 | transport | GO:0006810 | |||
| 1.2E-04 | chloride transport | GO:0006821 | |||
| 3.2E-04 | cell adhesion | GO:0007155 | |||
| 5.8E-04 | glycogen biosynthetic process | GO:0005978 | |||
| 3.7E-13 | protein amino acid phosphorylation | GO:0006468 | |||
| 2.0E-07 | protein amino acid dephosphorylation | GO:0006470 | |||
| 1.7E-06 | dephosphorylation | GO:0016311 | |||
| 2.4E-10 | regulation of transcription | GO:0045449 | |||
| 5.3E-10 | regulation of transcription, DNA-dependent | GO:0006355 | |||
| 9.1E-05 | transcription | GO:0006350 | |||
The gene groups used for the analysis were defined through a series of exact tests for NB distribution (Figure 3B). Over-represented GO terms with p-value<0.01 were included.