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. Author manuscript; available in PMC: 2012 Dec 8.
Published in final edited form as: J Med Chem. 2011 Nov 9;54(23):8207–8213. doi: 10.1021/jm2012003

Scheme 1.

Scheme 1

Likely mechanism and observed products7,10 in the reaction of 1,2,4-trioxolane 1 with inorganic ferrous iron. Reaction conditions: a) 1.0 equivalent ferrous bromide, tetrahydrofuran; b) 1.5 equivalents ferrous acetate, water-acetonitrile (1:1), 2.0 equivalents 4-(oxo)-TEMPO.