Table 3.

Center-specific and pooled associations between n-6 fatty acids and log(PAI-1)

	Standardized parameter estimates
	Total (n=915)	Caucasian men (n=304)	Japanese men (n=313)	Japanese- American men (n=298)
Total n-6 Fatty acids
Univariate	−0.27*	−0.32*	−0.25*	−0.27*
Model I	−0.32*	−0.32*	−0.24*	−0.27*
Model II	−0.24*	−0.18*	−0.20*	−0.21*
Model III	−0.13*	−0.06*	−0.12*	−0.10*
Model IV	−0.14*	−0.09*	−0.12*	−0.09*
Linoleic acid
Univariate	−0.23*	−0.29*	−0.20**	−0.23*
Model I	−0.24*	−0.29*	−0.19**	−0.23*
Model II	−0.17*	−0.15*	−0.15*	−0.18*
Model III	−0.10*	−0.07*	−0.07*	−0.12*
Model IV	−0.10*	−0.08*	−0.04*	−0.11*
Arachidonic acid
Univariate	−0.16*	−0.13***	−0.19**	−0.11
Model I	−0.14*	−0.13	−0.18**	−0.11
Model II	−0.10*	−0.08*	−0.17*	−0.07*
Model III	−0.01*	−0.003*	−0.10*	0.04*
Model IV	−0.01*	−0.003*	−0.10*	0.04*

^*p<0.001;

^**p<0.01;

^***p<0.05

Total n-6 fatty acids indicate the sum of linoleic acid (18:2n-6), gamma-linoleic acid (18:3n-6), dihomo-gamma-linolenic acid (20:3n-6) and arachidonic acid (20:4n-6).

Marine-derived n-3 fatty acids were defined as eicosapentaenoic acid (20:5n-3), docosapentaenoic acid (22:5n-3), and docosahexaenoic acid (22:6n-3).

Total n-3 fatty acids indicate marine-derived n-3 fatty acids, eicosatetraenoic acid (20:4n-3) and α-linolenic acid (22:18n-3).

Trans fatty acids indicate the sum of palmitelaidic acid (16n-7:1t), trans 9-octadecanoic acid (18n-9:1t) and linolelaidic acid (18n-6:2tt).

Model I: adjusted for age;

Model II: additionally adjusted for BMI, current smoking, alcohol drinker, hypertension, and diabetes;

Model III: further adjusted for LDL cholesterol, HDL cholesterol, triglycerides, and CRP (C-reactive protein);

Model IV: continuously adjusted for marine n-3 fatty acids, and trans fatty acids.