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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Int J Cancer. 2011 Aug 12;130(11):2539–2548. doi: 10.1002/ijc.26257

Fig. 4.

Fig. 4

VASP Ser239 phosphorylation by GCC disrupts colon cancer cell invadopodia. T84 cells were treated (with the PBS control or 1 μM ST to induce GCC signaling), imaged and analyzed for quantification of invadopodia as in Fig. 2c. Cancer cells stably expressed the indicated MSCV-driven genes (see Material and Methods for details), including the control VASP, and VASP-S157A (S157A), VASP-S239A (S239A) and VASP-AA (AA). Boxes in cartoons on left of top images indicate visual planes in vertical (upper panels) and horizontal (bottom panels) cross-sections from Z-stacks. *, P < 0.05 versus respective control.