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. 2011 Dec 6;1(2):e000290. doi: 10.1136/bmjopen-2011-000290

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© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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(A) Effect messages (positive and negative) organised along the research period, per year (2000–2009) and according to the source (scientific–medical journals and newspapers). (B) The natural logarithm of the positive-to-negative ratio was calculated and also plotted for the accumulated scientific–medical articles (green line), accumulated newspaper articles (red line) and solely research articles from the scientific–medical literature (dark blue line). *The grey zone illustrates the period where most of the regulatory warnings were issued. **Articles with a positive-effect trend are located above zero, while articles conveying a negative-effect trend are located underneath zero.