Table 2.

Overview of data for safety analysis using phase pairs

In the latter phase	MTX dosage (mg/week) in the former phase	2–4		Over 4–6		Over 6–8		8 or lower		Over 8
	Subtotal number of phase pairs	Number of phase pairs	%	Number of phase pairs	%	Number of phase pairs	%	Number of phase pairs	%	Number of phase pairs	%
Dosage the same as the former	17,495	5,249	56.0	5,052	55.3	4,273	57.3	14,574	56.1	2,921	54.2
Dosage different from the former	9,623	2,567	27.4	2,881	31.6	2,327	31.2	7,775	29.9	1,848	34.3
Discontinuation	1,417	655	7.0	345	3.8	228	3.1	1,228	4.7	189	3.5
Data not available	2,820	909	9.7	852	9.3	628	8.4	2,389	9.2	431	8.0
Total	31,355	9,380	100.0	9,130	100.0	7,456	100.0	25,966	100.0	5,389	100.0