Table 5.
Top 25 ranked TFs for five microarray derived gene sets using the abstract cooccurrence model.
| abstract co-occurrrence model | |||||
|---|---|---|---|---|---|
| Rank | Interferon | IL-4 | Tunicamycin | GH | TGF-β1 |
| 1 | Irf1 | Hif1a | Ddit3 | Nfkb1 | Hif1a |
| 2 | Stat1 | Sfpi1 | Egr1 | Stat1 | Egr1 |
| 3 | Irf9 | Tcfap2a | Gfi1 | Cebpb | Runx2 |
| 4 | Stat6 | Irf1 | Ppara | Rel | Smad3 |
| 5 | Stat4 | Rela | Ppard | Foxp3 | Sp1 |
| 6 | Nr3c1 | Egr1 | Tcfap2a | Kitl | Smad4 |
| 7 | Irf3 | Pparg | Tcf3 | Nfatc2 | Smad1 |
| 8 | Sfpi1 | Nfkb1 | Rara | Rela | Tcf3 |
| 9 | Myc | Stat1 | Zbtb16 | Irf1 | Nkx2-5 |
| 10 | Jund | Ikzf1 | Rarg | Stat6 | Tcf4 |
| 11 | Atf3 | Foxo1 | Cebpd | Jun | Elk3 |
| 12 | Ifi47 | Gata1 | Hoxa9 | Sfpi1 | Tcfap2a |
| 13 | Prdm1 | Itgal | Rxra | Cebpd | Tcf12 |
| 14 | Stat3 | Kitl | Hsf1 | Ddit3 | Smad7 |
| 15 | Foxn1 | Foxn1 | Nr5a1 | Foxn1 | Zbtb16 |
| 16 | Ep300 | Fosl1 | Pparg | Irf3 | Bcl6 |
| 17 | Usf1 | Stat6 | Otx1 | Ep300 | Pgr |
| 18 | Irf8 | Stat3 | Ep300 | Vdr | Cebpd |
| 19 | Bcl6 | Fos | Jund | Cebpa | Ep300 |
| 20 | Rxrb | Jun | Srebf1 | Fos | Smad2 |
| 21 | Hsf1 | Nfatc2 | Hand1 | E2f1 | Jun |
| 22 | Rela | Foxp3 | Hif1a | Sp1 | Foxo3 |
| 23 | Junb | Sp1 | Egr2 | Ppara | Pax5 |
| 24 | Fos | Foxo3 | Runx2 | Myb | Ppara |
| 25 | Stat2 | Pxn | Gata3 | Pax5 | Myod1 |
Ddit3 (in bold font) was the only ground truth TF ranked by this method. The ground truth TFs were chosen because they were targeted in the published study as critical regulators for each gene set.