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Binding characteristics of expressed receptor constructs. Values are means ± SEM from three experiments.
| Construct | Kd for [3H]NMS, nM | pIC50 for MT7 | p Kx for MT7 | Cooperativity factor α |
|---|---|---|---|---|
| M5 | 0.79 ± 0.16 | − | − | − |
| M5-ELYE | 0.54 ± 0.09 | 9.22 ± 0.11 | 9.48 ± 0.10 | 0.08 ± 0.02 |
| M5-EAYE | 0.49 ± 0.08 | 8.89 ± 0.04 | 9.16 ± 0.04 | 0.08 ± 0.01 |
| M5-ELY | 0.73 ± 0.09 | 8.21 ± 0.05 | 8.38 ± 0.04 | 0.21 ± 0.01 |
