Table 1.
Key findings on the associations between CRP and IL6 SNPs and risk of Alzheimer’s disease. The full data is presented in supplementary table 1.
| Gene/Marker | Controls N=2370 (%) |
AD cases N=1265 (%) |
OR (95% CI) | Ptrend | |
|---|---|---|---|---|---|
| CRP/rs1800947 | GG | 85.2 | 82.7 | 1 | |
| GC | 14.1 | 16.1 | 1.09 (0.90–1.31) | ||
| CC | 0.7 | 1.2 | 1.57 (0.79–3.74) | 0.22 | |
| CRP/rs1417938 | AA | 46.3 | 49.3 | 1 | |
| AT | 44.9 | 43.0 | 0.90 (0.79–1.04) | ||
| TT | 8.8 | 7.7 | 0.80 (0.62–1.03) | 0.04 | |
| IL6/rs2069861 | GG | 84 | 87 | 1 | |
| GA | 16 | 11 | 0.74 (0.60–0.90) | ||
| AA | 0.6 | 1 | 1.50 (0.76–2.99) | 0.04 | |
| IL6/rs12700386 | CC | 69 | 67 | 1 | |
| CG | 28 | 30 | 1.09 (0.94–1.27) | ||
| GG | 3 | 4 | 1.39 (0.96–2.01) | 0.08 | |
| IL6/rs2056576 | GG | 54 | 52 | 1 | |
| GA | 39 | 39 | 1.09 (0.94–1.25) | ||
| AA | 7 | 9 | 1.25 (0.97–1.61) | 0.07 | |
| IL6/rs1546762 | GG | 29 | 27 | 1 | |
| AG | 49 | 47 | 1.02 (0.88–1.20) | ||
| AA | 22 | 25 | 1.17 (0.97–1.43) | 0.12 |
Odds Ratios (OR) with 95% Confidence Intervals (CI) from Alternating Logistic Regression with the most common homozygote genotype as the reference level. Adjusted for age and sex.