Table 2.
Characteristics of the study population included in the analysis of hsCRP and IL6 in serum
| Nested case-control (incident) sample | Patient case-control (prevalent) sample | |||||
|---|---|---|---|---|---|---|
| Characteristic† | Dementia (N=179) | AD (N=91) | Controls (N=364) | Dementia (N=97) | AD (N=71) | Controls (N=205) |
| Age (years), mean±SD | 78.5 ± 6.3 | 79.5 ± 6.2 | 78.2 ± 6.6 | 81.7 ± 5.2 | 81.6 ± 5.3 | 81.3 ± 5.6 |
| Sex (women), N (%) | 110 (61.5) | 62 (68.1) | 219 (60.2) | 64 (66.0) | 52 (73.2) | 127 (62.0) |
| Low education, N (%) | 127 (71.0) | 69 (75.8) | 242 (66.5) | 76 (80.0)* | 54 (78.3)* | 128 (62.4) |
| Ever smokers, N (%) | 73 (40.8) | 38 (41.8) | 147 (40.4) | 39 (40.2) | 24 (33.8) | 93 (45.4) |
| Myocardial infarction, N (%) | 15 (8.4) | 4 (4.4) | 25 (6.9) | 9 (9.3)* | 3 (4.2) | 7 (3.4) |
| Stroke, N (%) | 8 (4.5) | 1 (1.1) | 18 (5.0) | 22 (22.7)** | 5 (7.0) | 14 (6.8) |
| Diabetes, N (%) | 10 (5.6) | 4 (4.4) | 9 (2.5) | 16 (16.5)** | 11 (15.5)** | 6 (2.9) |
| APOE4, N (%) | 70 (39.8)** | 36 (39.6)* | 87 (24.3) | 41 (43.2)** | 33 (47.2)** | 44 (22.3) |
| BMI (kg/m2), mean±SD | 25.5 ± 3.9 | 25.3 ± 4.0 | 25.5 ± 3.8 | 24.3 ± 3.5 | 24.0 ± 3.1* | 25.2 ± 4.3 |
| SBP (mmHg), mean±SD | 159.1 ± 23.2 | 158.1 ± 24.3 | 155.8 ± 22.0 | 146.3 ± 25.8* | 146.7 ± 25.2 | 153.0 ± 20.2 |
†
N based on all individuals with a hsCRP or IL6 measurement;
*
p<0.05,
**
p<0.001 comparing cases to controls Low education: elementary school or less;
BMI: Body Mass Index; SBP: Systolic Blood Pressure